According to the news the Spectre and Meltdown exploits are the end of computing as we know it. At least that is what I keep hearing. The truth is that these are just two (difficult to use) exploits out of hundreds.
What are you doing to protect your environment? Are you patching regularly, running anti-virus, content filtering, Gateway AV, intrusion prevention, and intrusion detection? Even if you are doing all of these things are you actively monitoring and re-mediating issues as they arise?